Shape of ligand immobilized particles dominates and amplifies the macrophage cytokine response to ligands.

ABSTRACT: Macrophages aid in clearing synthetic particulates introduced into the body and bridge innate and adaptive immunity through orchestrated secretion of cytokines and chemokines. While the field has made tremendous progress in understanding the effect of particle physicochemical properties on particle-macrophage interactions, it is not known how macrophage functions like cytokine production are affected while presenting active ligands on particles with altered physical properties. Moreover, it is unknown if ligand presentation through an altered particle shape can elicit differential macrophage cytokine responses and if responses are ligand dependent. Therefore, we investigated the influence of geometric particle presentation of diverse ligands, bovine serum albumin, immunoglobulin-G and oval

SUBMITTER: Garapaty A 

PROVIDER: S-EPMC6524819 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature