INSTI-Based Triple Regimens in Treatment-Naive HIV-Infected Patients Are Associated With HIV-RNA Viral Load Suppression at Ultralow Levels.

ABSTRACT:

Background

During antiretroviral therapy (ART), HIV-1-infected patients may present with ultralow (UL) HIV-RNA viral loads (VLs) below quantification levels of current assays. Reasons for UL-VL detection and its relation to virological rebound (VR) are unclear.

Methods

HIV-1-infected, ART-naïve patients followed at 2 university hospitals were included. All participants had an HIV-RNA >200 copies/mL at ART initiation and achieved a VL <50 copies/mL during ART. UL-VL was determined by the presence/absence of polymerase chain reaction signal detected using a commercially available assay (COBAS, TaqMan, Roche). Random-effects Poisson regression was used for assessing determinants of UL-VL not detected overtime and conditional risk set analysis for VR (1 VL > 200 copies/mL or 2 V

SUBMITTER: Lambert-Niclot S 

PROVIDER: S-EPMC6524833 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature