Calibrated Automated Thrombinography (CAT), a Tool to Identify Patients at Risk of Bleeding during Anticoagulant Therapy: A Systematic Review.

ABSTRACT: Background  Bleeding is a feared adverse event during anticoagulant treatment. In patients on vitamin K antagonists, most bleedings occur with the international normalized ratio (INR) in the therapeutic range. Currently, identification of high-risk patients via laboratory methods is not reliable. In this systematic review, we assessed the ability of calibrated automated thrombin generation (CAT-TG) to predict bleeding in patients on anticoagulant treatment. Methods  A systematic search was executed in three databases: Medline, Embase, and Cochrane. Results  Seven studies were included; two were of good methodological quality. One study showed that patients on warfarin with INRs in range (2-3) admitted for hemorrhage ( n  = 28), had lower CAT-TG levels (endogenous thrombin potential [ETP]:

SUBMITTER: Zwaveling S 

PROVIDER: S-EPMC6524885 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature