Activity Pattern Analysis Indicates Increased but Balanced Systemic Coagulation Activity in Response to Surgical Trauma.

ABSTRACT: In the nonbleeding patient, constant low-level activation of coagulation enables a quick procoagulant response upon an injury. Conversely, local activation of coagulation might influence the systemic activity level of coagulation. To characterize this interaction in more detail, activity pattern analysis was performed in patients undergoing elective surgeries. Blood samples were taken before, during, and 24 hours after surgery from 35 patients undergoing elective minor ( n  = 18) and major ( n  = 17) orthopaedic surgeries. Plasma levels of thrombin and activated protein C (APC) were measured using oligonucleotide-based enzyme capture assays, while those of prothrombin fragment 1.2, thrombin-antithrombin-complexes, and D-dimer were measured using commercially available enzyme-linked immunos

SUBMITTER: Friedrich MJ 

PROVIDER: S-EPMC6524900 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature