D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding.

ABSTRACT: Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. The study population comprised 555 patients with a first community-acquired VTE (1994-2016), who were identified among participants from the Tromsø study. Major bleeding events were recorded during the first year after VTE and defined according to the criteria of the International Society on Thrombosis and Haemostasis. Cox-regression was used to calculate hazard ratios (HRs) with 95% confiden

SUBMITTER: Johnsen HS 

PROVIDER: S-EPMC6524911 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature