Ontology highlight
ABSTRACT:
SUBMITTER: Battle SL
PROVIDER: S-EPMC6524944 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Battle Stephanie L SL Doni Jayavelu Naresh N Azad Robert N RN Hesson Jennifer J Ahmed Faria N FN Overbey Eliah G EG Zoller Joseph A JA Mathieu Julie J Ruohola-Baker Hannele H Ware Carol B CB Hawkins R David RD
Stem cell reports 20190502 5
During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the preimplantation blastocyst (naive) and postimplantation epiblast (primed), our data in 2iL/I/F naive cells demonstrate that a substantial portion of known human enhancers are premarked by H3K4me1, providing an enhanced open chromatin state in naive pluripotency. The 2iL/I/F enhancer repertoire occupies 9% of the genome, three ti ...[more]