BMI but not central obesity predisposes to airway closure during bronchoconstriction.

ABSTRACT:

Background and objective

Obesity produces restrictive effects on lung function. We previously reported that obese patients with asthma exhibit a propensity towards small airway closure during methacholine challenge which improved with weight loss. We hypothesized that increased abdominal adiposity, a key contributor to the restrictive effects of obesity on the lung, mediates this response. This study investigates the effect of body mass index (BMI) versus waist circumference (WC) on spirometric lung function, sensitivity to airway narrowing and closure, and airway closure during bronchoconstriction in patients with asthma.

Methods

Participants underwent spirometry and methacholine challenge. Sensitivity to airway closure and narrowing was assessed from the dose-response slop

SUBMITTER: Peters U 

PROVIDER: S-EPMC6525043 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature