Ontology highlight
ABSTRACT:
SUBMITTER: Cadena C
PROVIDER: S-EPMC6525047 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cell 20190418 5
The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling activity of the viral RNA receptor RIG-I through both Ub-dependent and -independent manners. RIPLET uses its dimeric structure and a bivalent binding mode to preferentially recognize and ubiquitinate RIG-I pre-oligomerized on dsRNA. In addition, RIPLET can cross-b ...[more]