Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression.

ABSTRACT: A defective homologous recombination (HR) repair program increases tumor incidence as well as providing a survival advantage in patients with breast and ovarian cancers. Here we hypothesize that the tumor-promoting side of genome maintenance programs may be contributed by a self-renewal protein, nucleostemin (NS). To address this issue, we established its functional importance in mammary tumor progression in mice and showed that mammary tumor cells become highly susceptible to replicative DNA damage following NS depletion and are protected from hydroxyurea-induced damage by NS overexpression. Breast cancer cells with basal-like characters display more reliance on NS for genome maintenance than those with luminal characters. Mechanistically, NS-deficient cells demonstrate a significantly re

SUBMITTER: Lin T 

PROVIDER: S-EPMC6525051 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature