Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink.

ABSTRACT:

Objective

To evaluate the association between statin use and risk of biliary tract cancers (BTC).

Design

This is a nested case-control study conducted in the UK Clinical Practice Research Datalink. We included cases diagnosed with incident primary BTCs, including cancers of the gall bladder, bile duct (ie, both intrahepatic and extrahepatic cholangiocarcinoma), ampulla of Vater and mixed type, between 1990 and 2017. For each case, we selected five controls who did not develop BTCs at the time of case diagnosis, matched by sex, year of birth, calendar time and years of enrolment in the general practice using incidence density sampling. Exposures were defined as two or more prescription records of statins 1 year prior to BTC diagnosis or control selection. ORs and 95% CIs for

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6525087 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature