Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.

ABSTRACT: Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on tumour-derived EVs remain unclear. Here we show that two classes of cytotoxic drugs broadly employed in pre-operative (neoadjuvant) breast cancer therapy, taxanes and anthracyclines, elicit tumour-derived EVs with enhanced pro-metastatic capacity. Chemotherapy-elicited EVs are enriched in annexin A6 (ANXA6), a Ca²⁺-dependent protein that promotes NF-κB-dependent endothelial cell activation, Ccl2 induction and Ly6C

SUBMITTER: Keklikoglou I 

PROVIDER: S-EPMC6525097 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature