The functional neuroanatomy of musical memory in Alzheimer's disease.

ABSTRACT:

Background

Memory for music has attracted much recent interest in Alzheimer's disease but the underlying brain mechanisms have not been defined in patients directly. Here we addressed this issue in an Alzheimer's disease cohort using activation fMRI of two core musical memory systems.

Methods

We studied 34 patients with younger onset Alzheimer's disease led either by episodic memory decline (typical Alzheimer's disease) or by visuospatial impairment (posterior cortical atrophy) in relation to 19 age-matched healthy individuals. We designed a novel fMRI paradigm based on passive listening to melodies that were either previously familiar or unfamiliar (musical semantic memory) and either presented singly or repeated (incidental musical episodic memory).

Results

Both syn

SUBMITTER: Slattery CF 

PROVIDER: S-EPMC6525150 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature