Analysis of haloarchaeal twin-arginine translocase pathway reveals the diversity of the machineries.

ABSTRACT: The twin-arginine translocase (Tat) pathway transports folded proteins across the plasma membrane and plays a critical role in protein transport in haloarchaea. Computational analysis and previous experimental evidence suggested that the Tat pathway transports almost the entire secretome in haloarchaea. The TatC, receptor component of this pathway shows greater variation in membrane topology in haloarchaea than in other organisms. The presence of a unique fourteen-transmembrane TatC homolog (TatC_t) in haloarchaea, over and above the expected TatC topological variants, indicates a strong correlation between the additional homologs and the large number of substrates transported via the haloarchaeal Tat pathway. Various combinations of TatC homologs with different topologies-TatC

SUBMITTER: Ghosh D 

PROVIDER: S-EPMC6525301 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature