Ontology highlight
ABSTRACT:
SUBMITTER: Gu Z
PROVIDER: S-EPMC6525306 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20190114 2
Recent genomic studies have identified chromosomal rearrangements defining new subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL), however many cases lack a known initiating genetic alteration. Using integrated genomic analysis of 1,988 childhood and adult cases, we describe a revised taxonomy of B-ALL incorporating 23 subtypes defined by chromosomal rearrangements, sequence mutations or heterogeneous genomic alterations, many of which show marked variation in prevalence according to ...[more]