PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis.

ABSTRACT: Sepsis-associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis-associated AKI are poorly understood. Previous research has demonstrated that peroxisome proliferator-activated receptor α (PPARα) expression is associated with reduced organ system failure in sepsis. Using an experimental model of polymicrobial sepsis, we demonstrate that mice deficient in PPARα have worse kidney function, which is likely related to reduced fatty acid oxidation and increased inflammation. Ultrastructural evaluation with electron microscopy reveals that the proximal convoluted tubule is specifically injured in septic PPARα deficient mice. In this experimental group, serum met

SUBMITTER: Iwaki T 

PROVIDER: S-EPMC6525329 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature