Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis.

ABSTRACT:

Background

We retrieved different reports containing different genetic effects of - 1082 A/G, - 819 T/C, and - 592 A/C polymorphisms within the IL-10 (interleukin-10) gene on the susceptibility to clinical atopic dermatitis.

Methods

Herein, we conducted a meta-analysis to comprehensively assess such a genetic relationship after collecting the available published evidence. STATA 12.0 software was used for the statistical analysis under the allelic, homozygotic, heterozygotic, dominant, recessive and carrier genetic models.

Results

By retrieving and screening database literature, a total of 16 eligible case-control studies were finally selected. For the IL-10 -1082 A/G polymorphism, we did not detect a significant difference between atopic dermatitis cases and populatio

SUBMITTER: Qi Y 

PROVIDER: S-EPMC6525399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature