Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications.

ABSTRACT:

Background

Heterogeneity and lack of targeted therapies represent the two main impediments to precision treatment of triple-negative breast cancer (TNBC), and therefore, molecular subtyping and identification of therapeutic pathways are required to optimize medical care. The aim of the present study was to define robust TNBC subtypes with clinical relevance.

Methods

Gene expression profiling by means of DNA chips was conducted in an internal TNBC cohort composed of 238 patients. In addition, external data (n = 257), obtained by using the same DNA chip, were used for validation. Fuzzy clustering was followed by functional annotation of the clusters. Immunohistochemistry was used to confirm transcriptomics results: CD138 and CD20 were used to test for plasma cell and B lymphoc

SUBMITTER: Jezequel P 

PROVIDER: S-EPMC6525459 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature