Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila.

ABSTRACT: The ecdysone pathway was among the first experimental systems employed to study the impact of steroid hormones on the genome. In Drosophila and other insects, ecdysone coordinates developmental transitions, including wholesale transformation of the larva into the adult during metamorphosis. Like other hormones, ecdysone controls gene expression through a nuclear receptor, which functions as a ligand-dependent transcription factor. Although it is clear that ecdysone elicits distinct transcriptional responses within its different target tissues, the role of its receptor, EcR, in regulating target gene expression is incompletely understood. In particular, EcR initiates a cascade of transcription factor expression in response to ecdysone, making it unclear which ecdysone-responsive gene

SUBMITTER: Uyehara CM 

PROVIDER: S-EPMC6525475 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature