Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria.

ABSTRACT: Mitochondria are tubular double-membrane organelles essential for eukaryotic life. They form extended networks and exhibit an intricate inner membrane architecture. The MICOS (mitochondrial contact site and cristae organizing system) complex, crucial for proper architecture of the mitochondrial inner membrane, is localized primarily at crista junctions. Harnessing superresolution fluorescence microscopy, we demonstrate that Mic60, a subunit of the MICOS complex, as well as several of its interaction partners are arranged into intricate patterns in human and yeast mitochondria, suggesting an ordered distribution of the crista junctions. We show that Mic60 forms clusters that are preferentially localized in the inner membrane at two opposing sides of the mitochondrial tubules so that they fo

SUBMITTER: Stoldt S 

PROVIDER: S-EPMC6525524 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature