In Vivo Formation of Stable Hyaline Cartilage by Naive Human Bone Marrow Stromal Cells with Modified Fibrin Microbeads.

ABSTRACT: Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) have been suggested as an adequate cell source for cartilage reconstruction. However, the majority of studies employing BMSCs for cartilage tissue engineering have used BMSCs predifferentiated into cartilage prior to implantation. This strategy has failed to achieve formation of stable, hyaline-like cartilage, resistant to hypertrophy in vivo. We hypothesized that in vitro predifferentiation of BMSCs is not necessary when cells are combined with an adequate scaffold that suppor

SUBMITTER: Kuznetsov SA 

PROVIDER: S-EPMC6525579 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature