Cells released from S. epidermidis biofilms present increased antibiotic tolerance to multiple antibiotics.

ABSTRACT: Biofilm released cells (Brc) are thought to present an intermediary phenotype between biofilm and planktonic cells and this has the potential of affecting their antimicrobial tolerance.

Aim

Compare the antimicrobial tolerance profiles of Brc, planktonic or biofilm cultures of S. epidermidis.

Methodology

Planktonic, biofilm cultures or Brc from 11 isolates were exposed to peak serum concentrations (PSC) of antibiotics. The antimicrobial killing effect in the three populations was determined by CFU.

Results

Increased Brc tolerance to vancomycin, teicoplanin, rifampicin, erythromycin, and tetracycline was confirmed in model strain 9142. Furthermore, significant differences in the susceptibility of Brc to vancomycin were further found in 10 other clinical isolates.<

SUBMITTER: Gaio V 

PROVIDER: S-EPMC6525591 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature