Identification of CD8α⁺ dendritic cells in rainbow trout (Oncorhynchus mykiss) intestine.

ABSTRACT: Dendritic cells (DCs) are professional antigen presenting cells located at mucosal surfaces and lymphoid tissues. Their main role is to present antigens to T cells and thus regulate the initiation of the acquired immune response and modulate tolerance mechanisms towards self-antigens. Despite their relevance, not many studies have addressed the identification and characterization of specific DC subsets in teleost fish. Previous studies in our group identified a DC subpopulation co-expressing CD8α and major histocompatibility complex II (MHC II) on the cell surface in rainbow trout (Oncorhynchus mykiss) skin and gills. A complete functional and phenotypical characterization of these cell subsets was then undertaken, unequivocally recognizing them as DCs (CD8⁺ DCs). In the current

SUBMITTER: Soleto I 

PROVIDER: S-EPMC6525785 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature