Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis.

ABSTRACT:

Purpose

The Oct4 gene plays an important role in undifferentiated embryonic stem cells and regulates stem cell pluripotency. The aim of this study was to examine the relationship between Oct4 expression and liver metastasis of colorectal cancer (CRC) in clinical samples and investigate the role and abilities of Oct4-positive CRC cells.

Methods

The study included 158 patients who underwent surgery for CRC between 2009 and 2011. The correlations between the Oct4 gene expression and the clinical parameters were assessed, and liver metastasis-free survival (LMFS) was evaluated in these patients. Oct4-EGFP-positive cells were established to examine their subpopulation and ability. The capacity to form liver metastasis in vivo was examined using CRC cell lines and pr

SUBMITTER: Fujino S 

PROVIDER: S-EPMC6525814 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature