Association between Metformin Use and Coronary Artery Calcification in Type 2 Diabetic Patients.

ABSTRACT:

Objectives

Type 2 diabetes mellitus (T2DM) is associated with coronary artery calcification (CAC) which is an independent risk factor for cardiovascular events. Metformin is the first-line antidiabetic medication. We aimed to investigate the association between metformin use and CAC.

Methods

We included 369 patients with T2DM in this cross-sectional study. CAC scores, clinical characteristics, and antidiabetic drug prescription information of the patients were acquired. Baseline parameters were balanced for metformin and nonmetformin users using the propensity score matching (PSM) strategy.

Results

Among the 369 subjects who met our inclusion criteria, 288 subjects were included for further analysis after PSM. Metformin prescription rather than other antidiabetic medi

SUBMITTER: Lu Y 

PROVIDER: S-EPMC6525896 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature