Microfluidic device for expedited tumor growth towards drug evaluation.

ABSTRACT: Patient derived organoids have emerged as robust preclinical models for screening anti-cancer therapeutics. Current 2D culturing methods do not provide physiological responses to therapeutics, therefore 3D models are being developed to better reproduce physiological responses. 3D culturing however often requires large initial cell populations and one week to one month to grow tumors ready for therapeutic testing. As a solution a 3D culturing system has been developed capable of producing physiologically relevant tumors in an expedited fashion while only requiring a small number of initial cancer cells. A bi-layer microfluidic system capable of facilitating active convective nutrient supply to populations of cancer cells facilitates expedited growth of cancer cells when starting with popula

SUBMITTER: Uhl CG 

PROVIDER: S-EPMC6526058 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature