Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice.

ABSTRACT: Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability of rodents in simple and direct ways, which includes reciprocal social interaction, juvenile social play, and three-chamber social tests. There are possible confounding factors while performing some of these tasks, such as aggression, avoidance of interaction by the stimulus mouse, exposure to a new environment, and lengthy procedures. The present study devised a method to complement these shortcomings and measure sociability as a group in the home cage setting, which prevents group-housed mice from isolation or exposure to a new environment. The home cage social test can allow hi

SUBMITTER: Kim DG 

PROVIDER: S-EPMC6526108 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature