Cytoreductive prostatectomy in metastatic prostate cancer: current knowledge and future directions.

ABSTRACT: The current standard of care for patients with metastatic prostate cancer is systemic androgen deprivation therapy, and addressing the primary tumor has been reserved for patients with localized disease. However, emerging data has called into question the universality of this paradigm. Recent studies have found treatment of the primary tumor in patients with metastatic disease not only can provide the patient with symptomatic relief but also may provide a survival benefit. The potential biological and clinical benefit for cytoreductive surgery has been also been suggested in several translational models. Thus, PubMed electronic database was queried for publications on patients with metastatic prostate cancer who underwent cytoreductive prostatectomy, using keywords including: cytoreductive

SUBMITTER: Polotti CF 

PROVIDER: S-EPMC6526356 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature