New quantitative approach reveals heterogeneity in mitochondrial structure-function relations in tumor-initiating cells.

ABSTRACT: Steady-state mitochondrial structure or morphology is primarily maintained by a balance of opposing fission and fusion events between individual mitochondria, which is collectively referred to as mitochondrial dynamics. The details of the bidirectional relationship between the status of mitochondrial dynamics (structure) and energetics (function) require methods to integrate these mitochondrial aspects. To study the quantitative relationship between the status of mitochondrial dynamics (fission, fusion, matrix continuity and diameter) and energetics (ATP and redox), we have developed an analytical approach called mito-SinCe2 After validating and providing proof of principle, we applied mito-SinCe2 on ovarian tumor-initiating cells (ovTICs). Mito-SinCe2 analyses led to the hypothesis that m

SUBMITTER: Spurlock B 

PROVIDER: S-EPMC6526706 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature