Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
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ABSTRACT:
SUBMITTER: Niu C
PROVIDER: S-EPMC6526809 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Niu Chao C Chen Zhiwei Z Kim Kyoung Tae KT Sun Jia J Xue Mei M Chen Gen G Li Santie S Shen Yingjie Y Zhu Zhongxin Z Wang Xu X Liang Jiaojiao J Jiang Chao C Cong Weitao W Jin Litai L Li Xiaokun X
Autophagy 20190127 5
Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under diabetic conditions are very limited. Clinical evidence establishes an endothelial protective effect of metformin, but the underlying mechanisms remain unclear. We aimed to investigate whether metformin exerts its protective role against hyperglycemia-induced endothelial impairment through the autophagy machinery. db/db mice were treated with intravitreal metformin injections. Human umbilical vein endothelia ...[more]
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