Comprehensive transcriptional profiling of aging porcine liver.

ABSTRACT:

Background

Aging is a major risk factor for the development of many diseases, and the liver, as the most important metabolic organ, is significantly affected by aging. It has been shown that the liver weight tends to increase in rodents and decrease in humans with age. Pigs have a genomic structure, with physiological as well as biochemical features that are similar to those of humans, and have therefore been used as a valuable model for studying human diseases. The molecular mechanisms of the liver aging of large mammals on a comprehensive transcriptional level remain poorly understood. The pig is an ideal model animal to clearly and fully understand the molecular mechanism underlying human liver aging.

Methods

In this study, four healthy female Yana pigs (an indigenous Chi

SUBMITTER: Chen J 

PROVIDER: S-EPMC6526898 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature