Genome Sequencing Verifies Relapsed Infection of Helicobacter cinaedi.

ABSTRACT:

Background

Recurrent infections of Helicobacter cinaedi are often reported, and long-term antimicrobial treatment is empirically recommended to prevent such infections. However, there have been no studies examining whether recurrent infections are relapses of former infections or reinfections with different clones.

Methods

A 69-year-old woman presented with recurrent H cinaedi bacteremia-associated cellulitis after a 51-day interval. We isolated 10 colonies from the blood cultures obtained during each of the 2 episodes and subjected them to whole-genome sequencing (WGS). High-confidence single-nucleotide polymorphisms (SNPs) were identified by an assembly based method. Heterogeneous SNP sites were identified by read mapping. The susceptibility of a representati

SUBMITTER: Sawada O 

PROVIDER: S-EPMC6527084 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature