The effect of flow on blood oxygen level dependent (R^*₂ ) MRI of orthotopic lung tumors.

ABSTRACT:

Purpose

Blood oxygen level dependent (BOLD) MRI based on R2* measurements can provide insights into tumor vascular oxygenation. However, measurements are susceptible to blood flow, which may vary accompanying a hyperoxic gas challenge. We investigated flow sensitivity by comparing R2* measurements with and without flow suppression (fs) in 2 orthotopic lung xenograft tumor models.

Methods

H460 (n = 20) and A549 (n = 20) human lung tumor xenografts were induced by surgical implantation of cancer cells in the right lung of nude rats. MRI was performed at 4.7T after tumors reached 5 to 8 mm in diameter. A multiecho gradient echo MRI sequence was acquired with and without spatial saturation bands on each side of the imaging plane to evaluate the effect of flow on R2* . fs and non

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6527131 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature