Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device.

ABSTRACT: Tissue-engineered devices have the potential to significantly improve human health. A major impediment to the success of clinically scaled transplants, however, is insufficient oxygen transport, which leads to extensive cell death and dysfunction. To provide in situ supplementation of oxygen within a cellular implant, we developed a hydrolytically reactive oxygen generating material in the form of polydimethylsiloxane (PDMS) encapsulated solid calcium peroxide, termed OxySite. Herein, we demonstrate, for the first time, the successful implementation of this in situ oxygen-generating biomaterial to support elevated cellular function and efficacy of macroencapsulation devices for the treatment of type 1 diabetes. Under extreme hypoxic conditions, devices supplemented with OxySite exhibited s

SUBMITTER: Coronel MM 

PROVIDER: S-EPMC6527135 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature