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The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.

ABSTRACT:

Conclusions

These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.

SUBMITTER: Sales-Dias J

PROVIDER: S-EPMC6527237 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.

Sales-Dias Joana J Silva Gabriela G Lamy Márcia M Ferreira Andreia A Barbas Ana A

PloS one 20190520 5

<h4>Conclusions</h4>These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms. ...[more]

PMID: 31107884

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Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.

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Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.

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Identification of Notch ligand useage by splenic B cells using Dll1 and Dll4 Notch ligand blockade.

Project description:Identification of Notch ligand useage by splenic B cells using Dll1 and Dll4 Notch ligand blockade.

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Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.

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