Alzheimer Disease-associated Cortical Atrophy Does not Differ Between Chinese and Whites.

ABSTRACT:

Purpose

To assess whether there are differences in Alzheimer disease (AD)-associated atrophy regions in Chinese and white patients with AD versus cognitively normal older adults, and to test whether associations between clinical severity and gray matter volume are similar or different across these ethnic groups in a cross-sectional analysis.

Materials and methods

Chinese and white patients with AD, individuals with mild cognitive impairment, and cognitively normal controls (46 white and 48 Chinese) were clinically evaluated at an academic center within 1 year of magnetic resonance imaging acquisition. Clinical severity was assessed using the Clinical Dementia Rating Sum of Boxes and cortical atrophy was measured using voxel-based morphometry as well as Freesurfer. Chinese an

SUBMITTER: Fan J 

PROVIDER: S-EPMC6527333 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature