IRF4-dependent dendritic cells regulate CD8⁺ T-cell differentiation and memory responses in influenza infection.

ABSTRACT: Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual vaccination to select strains. Development of vaccines that elicit lung-resident memory CD8⁺ T cells (T_RM) would offer more universal protection to seasonal and emerging pandemic viruses. Understanding how lung-resident dendritic cells (DCs) regulate T_RM differentiation would be an important step in this process. Here, we used CD11c-cre-Irf4^f/f (KO) mice, which lack lung-resident IRF4-dependent CD11b⁺CD24^hi DCs and show IRF4 deficiency in other lung cDC subsets, to determine if IRF4-expressing DCs regulate CD8⁺ memory precursor cells and T_RM during influenza A virus (IAV) infection. KO mice showed defective CD8

SUBMITTER: Ainsua-Enrich E 

PROVIDER: S-EPMC6527354 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature