Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.

ABSTRACT: Obesity is fundamentally a disorder of energy balance. In obese individuals, more energy is consumed than is expended, leading to excessive weight gain through the accumulation of adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and the development of Type II diabetes, make obesity one of the leading preventable causes of morbidity and mortality. Thus, it is of paramount importance to both individual and public health that we understand the neural circuitry underlying the behavioral regulation of energy balance. To this end, we sought to examine obesity-related differences in the resting state functional connectivity of the dorsal mid-insula, a region of gustatory and interoceptive cortex associated with homeostatically

SUBMITTER: Avery JA 

PROVIDER: S-EPMC6527420 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature