Krt5⁺/Krt15⁺ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress.

ABSTRACT: The effective prevention of tumor initiation, especially for potentially inoperable tumors, will be beneficial to obtain an overall higher quality of our health and life. Hence, thorough understanding of the pathophysiological mechanisms of early tumor formation arising from identifiable cellular origins is required to develop efficient preventative and early treatment options for each tumor type. Here, using genetically engineered mouse models, we provide preclinical experimental evidence for a long-standing open question regarding the pathophysiological potential of a microenvironmental and physiological stressor in tumor development, gastric acid-mediated regional microscopic injury in foregut squamous epithelia. This study demonstrates the association of gastric acid stress with Cycloo

SUBMITTER: Moon H 

PROVIDER: S-EPMC6527614 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature