Maternal heat stress regulates the early fat deposition partly through modification of m⁶A RNA methylation in neonatal piglets.

ABSTRACT: It is known that heat stress induces various physiological challenges in livestock production including changes in lipid metabolism. However, the molecular mechanism of how heat stress regulates lipid metabolism at the mRNA level is still largely unknown. N⁶-methyl-adenosine (m⁶A) is the most common and abundant modification on RNA molecules present in eukaryotes, which affects almost all aspects of RNA metabolism and thus gives us the hint that it may participate in changes of gene expression of lipid metabolism during heat stress. Therefore, the purpose of the present study was to investigate the effect of heat stress on fat metabolism in 21-day Large White × Landrace piglets from sows challenged by heat stress from day 85 of gestation until day 21 of lactation. We

SUBMITTER: Heng J 

PROVIDER: S-EPMC6527640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature