A Novel Mathematical Model for Studying Antimicrobial Interactions Against Campylobacter jejuni.

ABSTRACT: The aim of this study is to investigate the antimicrobial synergistic effect against Campylobacter jejuni, a leading foodborne pathogen that causes human gastroenteritis, by cinnamon oil, encapsulated curcumin, and zinc oxide nanoparticles (ZnO NPs). We compared three approaches to study the antimicrobial interactions, including the time-killing method, the fractional inhibitory concentration index (FICI) method, and a mathematical concentration-effect model. Isobologram analysis was performed to evaluate the synergy in different combinations, and a median-effect equation was applied to identify the combinations of synergistic effects at median, bacteriostatic, and bactericidal reduction levels. The time-killing method overestimated the synergistic interaction between antimicrobials

SUBMITTER: Hakeem MJ 

PROVIDER: S-EPMC6527739 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature