Everything You Always Wanted to Know About Salmonella Type 1 Fimbriae, but Were Afraid to Ask.

ABSTRACT: Initial attachment to host intestinal mucosa after oral infection is one of the most important stages during bacterial pathogenesis. Adhesive structures, widely present on the bacterial surface, are mainly responsible for the first contact with host cells and of host-pathogen interactions. Among dozens of different bacterial adhesins, type 1 fimbriae (T1F) are one of the most common adhesive organelles in the members of the Enterobacteriaceae family, including Salmonella spp., and are important virulence factors. Those long, thin structures, composed mainly of FimA proteins, are responsible for recognizing and binding high-mannose oligosaccharides, which are carried by various glycoproteins and expressed at the host cell surface, via FimH adhesin, which is presented at the to

SUBMITTER: Kolenda R 

PROVIDER: S-EPMC6527747 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature