Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways.

ABSTRACT: Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV⁺ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely unknown. Here, we investigated whether stimulation of ventral striatal (accumbal) PV⁺ interneurons would drive emotional valence in mice. We found that during conditioned place preference (CPP) training, activation of accumbal PV⁺ interneurons evoked place preference while suppressing them resulted in conditioned place aversion (CPA). Activation of PV⁺ interneurons during place conditioning increased Fos expression in SPNs in the direct pathway (dSPNs) and impaired lithium chloride-induced

SUBMITTER: Chen X 

PROVIDER: S-EPMC6527764 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature