IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions.

ABSTRACT: The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their production is particularly important in the context of mucosal defenses, through handling breach of the delicate epithelial barrier and mediating a local immune response to invading pathogens. Mucosal immunity is often aberrantly orchestrated in intestinal diseases, such as Inflammatory Bowel Disease (IBD). Various studies have pointed to IL-1 cytokines as being important players in IBD with context-dependent roles, either through promoting auto-inflammatory mechanisms, or alleviating disease through protection against breach of pathogens across the epithelial barrier. This m

SUBMITTER: Williams MA 

PROVIDER: S-EPMC6527769 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature