A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle.

ABSTRACT: Genome-wide association study (GWAS) is a powerful approach to identify genomic regions and genetic variants associated with phenotypes. However, only limited mutual confirmation from different studies is available. We conducted a large-scale GWAS using 294,079 first-lactation Holstein cows and identified new additive and dominance effects on five production traits, three fertility traits, and somatic cell score. Four chromosomes had the most significant SNP effects on the five production traits, a Chr14 region containing DGAT1 mostly had positive effects on fat yield and negative effects on milk and protein yields, the 88.07-89.60 Mb region of Chr06 with SLC4A4, GC, NPFFR2, and ADAMTS3 for milk and protein yields, the 30.03-36.67 Mb region of Chr20 with C6 and

SUBMITTER: Jiang J 

PROVIDER: S-EPMC6527781 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature