Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

ABSTRACT: Individuals differ substantially in their response to pharmacological treatment. Personalized medicine aspires to embrace these inter-individual differences and customize therapy by taking a wealth of patient-specific data into account. Pharmacogenomic constitutes a cornerstone of personalized medicine that provides therapeutic guidance based on the genomic profile of a given patient. Pharmacogenomics already has applications in the clinics, particularly in oncology, whereas future development in this area is needed in order to establish pharmacogenomic biomarkers as useful clinical tools. In this review we present an updated overview of current and emerging pharmacogenomic biomarkers in different therapeutic areas and critically discuss their potential to transform clinical care. Furtherm

SUBMITTER: Lauschke VM 

PROVIDER: S-EPMC6527860 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature