ERAP1 allotypes shape the epitope repertoire of virus-specific CD8⁺ T cell responses in acute hepatitis C virus infection.

ABSTRACT:

Background & aims

Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms are linked with human leukocyte antigen (HLA) class I-associated autoinflammatory disorders, including ankylosing spondylitis and Behçet's disease. Disease-associated ERAP1 allotypes exhibit distinct functional properties, but it remains unclear how differential peptide trimming in vivo affects the repertoire of epitopes presented to CD8⁺ T cells. The aim of this study was to determine the impact of ERAP1 allotypes on the virus-specific CD8⁺ T cell epitope repertoire in an HLA-B*27:05⁺ individual with acute hepatitis C virus (HCV) infection.

Methods

We performed genetic and functional analyses of ERAP1 allotypes and characterized the HCV-specific CD8⁺ T

SUBMITTER: Kemming J 

PROVIDER: S-EPMC6527866 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature