Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder.

ABSTRACT: Alterations in large-scale brain intrinsic functional connectivity (FC), i.e., coherence between fluctuations of ongoing activity, have been implicated in major depressive disorder (MDD). Yet, little is known about the frequency-dependent alterations of FC in MDD. We calculated frequency specific degree centrality (DC) - a measure of overall FC of a brain region - within 10 distinct frequency sub-bands accessible from the full range of resting-state fMRI BOLD fluctuations (i.e., 0.01-0.25 Hz) in 24 healthy controls and 24 MDD patients. In healthy controls, results reveal a frequency-specific spatial distribution of highly connected brain regions - i.e., hubs - which play a fundamental role in information integration in the brain. MDD patients exhibited significant deviations from the healt

SUBMITTER: Ries A 

PROVIDER: S-EPMC6527901 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature