Safety and efficacy of herbal medicine for acute intracerebral hemorrhage (CRRICH): a multicentre randomised controlled trial.

ABSTRACT:

Objective

To evaluate the safety and efficacy of removing blood stasis (RBS) herbal medicine for the treatment of acute intracerebral haemorrhage (AICH) within a 6-hour time window.

Study design

A randomised, multicentre, double-blind, placebo-controlled study performed in 14 hospitals in China.

Participants and interventions

Patients with AICH were randomly assigned to receive a placebo, the ICH-1 (Intracerebral Haemorrhage) formula (eight herbs, including the RBS herbs hirudo and tabanus) or the ICH-2 formula (six herbs without the RBS herbs hirudo and tabanus) within 6 hours of ICH onset.

Outcomes

The primary safety outcome was the incidence of haematoma enlargement at 24 hours and at 10 days after treatment. The secondary outcome

SUBMITTER: Zeng L 

PROVIDER: S-EPMC6528012 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature