Association Between rs1051730 and Smoking During Pregnancy in Dutch Women.

ABSTRACT:

Introduction

The common genetic variant (rs1051730) in the 15q24 nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 was associated with smoking quantity and has been reported to be associated also with reduced ability to quit smoking in pregnant women but results were inconsistent in nonpregnant women. The aim of this study was to explore the association between rs1051730 and smoking cessation during pregnancy in a sample of Dutch women.

Methods

Data on smoking during pregnancy were available from 1337 women, who ever smoked, registered at the Netherlands Twin Register (NTR). Logistic regression was used to assess evidence for the association of rs1051730 genotype on smoking during pregnancy. In a subsample of 561 women, we investigated the influence of partn

SUBMITTER: Mbarek H 

PROVIDER: S-EPMC6528154 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature