Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria.

ABSTRACT:

Background

Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown.

Methods

Ugandan children with cerebral malaria (CM, n = 260) and severe malaria anemia (SMA, n = 219) or community children (CC, n = 173) between 1.5 and 12 years of age were enrolled in a prospective cohort study. Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used to retrospectively define AKI and chronic kidney disease (CKD). Cognitive testing was conducted using the Mullen Scales of Early Learning in children < 5 and Kaufman Assessment Battery for Children (K-ABC) second edition in children ≥ 5 years of age.

Results

The prevalence of AKI was 35.1%, ranging from 25.1% in SMA to 43.5% in CM. In-hospital mortality

SUBMITTER: Conroy AL 

PROVIDER: S-EPMC6528242 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature